BioXCell BE0146 說明書

世界*實驗材料供應商 BioXCell 正式授權(quán)上海起發(fā)為其中國代理， BioXCell 在一直是行業(yè)的*,一直為廣大科研客戶提供zui為的產(chǎn)品和服務(wù),上海起發(fā)一直秉承為中國科研客戶帶來的產(chǎn)品，的服務(wù)，簽約 BioXCell 就是為了給廣大科研客戶帶來更加完善的產(chǎn)品和服務(wù),您的滿意將是我們zui大的收獲

BioXCell 中國代理, BioXCell 上海代理， BioXCell 北京代理，BioXCell 廣東代理， BioXCell 江蘇代理BioXCell 湖北代理,BioXCell 天津,BioXCell 黑龍江代理,BioXCell 內(nèi)蒙古代理,BioXCell 吉林代理,BioXCell福建代理, BioXCell 江蘇代理, BioXCell 浙江代理, BioXCell 四川代理,

Bio X Cell是一家位于美國新罕*爾州West Lebanon的生產(chǎn)用于生物醫(yī)學研究的高品質(zhì)、散裝（毫克至克級）單克隆抗體的生物技術(shù)公司，該公司專業(yè)供應高純度、低內(nèi)毒素的抗體、重組蛋白、融合蛋白的高科技生物技術(shù)公司，供應規(guī)模可從毫克至克。因該公司具有超過15年的單克隆抗體和重組蛋白的定制生產(chǎn)經(jīng)驗，其研發(fā)的抗體采用先進的細胞培養(yǎng)生物反應器技術(shù)從培養(yǎng)組織中提取，并通過親和層析純化，進而保證了其高純度（>95％），低內(nèi)毒素（<2 EU /毫克）特性，并且不添加防腐劑或穩(wěn)定劑，因而特別適合科研、制藥和診斷行業(yè)的臨床前研究。如客戶機研究人員使用本公司抗體（需在銷售后六個月內(nèi)，并遵循本公司推薦的試劑儲存方式）不能得到可出版的效果，本公司承諾將全部更換產(chǎn)品。而該公司生產(chǎn)的重組蛋白采用的發(fā)酵和純化技術(shù)，確保得到高活性和高純度的重組蛋白，目前Bio X cell公司具有所有主要表達系統(tǒng)進行重組蛋白的表達，包括：CHO、NSO、293、昆蟲細胞、大腸桿菌和酵母表達系統(tǒng)，并且采用的發(fā)酵技術(shù)，如攪拌槽內(nèi)發(fā)酵和Wavebag系統(tǒng)，生產(chǎn)能力范圍從5-500L。BioXCell還有相應的 FC-region，his標簽，flag標簽和GST親和標簽的重組蛋白的純化設(shè)備和純化經(jīng)驗。。此外，BioXCell提供相應的發(fā)酵和純化定制服務(wù)，根據(jù)客戶要求提供單克隆抗體雜交瘤細胞以及來源于哺乳動物，昆蟲和微生物表達系統(tǒng)如CHO，293，桿狀病毒ES，酵母，大腸桿菌等重組蛋白的發(fā)酵和純化服務(wù)。

InVivoMAb anti-mouse PD-1 (CD279)

Clone     RMP1-14

Catalog #  BE0146

Category   InVivoMab Antibodies

The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. PD-1 expression declines after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease in mice as PD-1 knockout animals show dilated cardiomyopathy, splenomegaly, and loss of peripheral tolerance. Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma, and breast adenocarcinoma. PD-L1 overexpression results in increased resistance of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and its receptor PD-1. For these reasons anti-PD-1 mediated immunotherapies are currently being explored as cancer treatments. Like the J43 antibody the RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.

我們公司zui大優(yōu)勢是強大的采購，

1：基本什么都能進口，血清，抗體，耗材，還有部分限制進口的，

2：貨品全，現(xiàn)經(jīng)營過700多個品牌，基本所有生物試劑耗材都可以進口，特別是冷偏的產(chǎn)品那就更有優(yōu)勢，

3：提供加急服務(wù)，一般1-2周到貨，超過時限加急費全免

4：價格公道，絕大部分價格有優(yōu)勢，當然不能保證100%產(chǎn)品都是,因為意味著沒有服務(wù).

5：良好的信譽，大部分客戶我們提供貨到付款服務(wù)，客戶包括清華，北大 交大 復旦，中山等100多所大學，ROCHE，阿斯利康，國藥 ，fisher等500多家公司

6：我們*代理的品牌有：Antibody Research Corporation，arcticzymes，Biorelevant，AmberGen, Inc. ，clemente-associates，clodronaiposomes，Columbia Biosciences，enzyme research，Gene Bridges GmbH，Genovis，AmberGen, Inc.  Biotechnology GmbH，Haematologic Technologies HTI Haemtech，hookelabs，Immudex，Innovative Research of America，inspiralis ，List Biological Laboratories, Inc.，lumafluor，Microsurfaces，multiplicom，nanotools，Pel-Freez Biologicals，pentapharm，progen，Protein Ark，QA-Bio,Inc，QA-Bio,IncQuickZyme Biosciences，Teknova，TriLink BioTechnologies, Inc.，Zyagen Laboratories 等

7：我們還是invitrogen,qiagen,Midland BioProducts Corporationam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知名*批發(fā)，歡迎合作。