KAMIYA PC-543 說明書

世界*實驗材料供應(yīng)商 KAMIYA正式授權(quán)上海起發(fā)為其中國代理， KAMIYA在一直是行業(yè)的*,一直為廣大科研客戶提供zui為的產(chǎn)品和服務(wù),上海起發(fā)一直秉承為中國科研客戶帶來的產(chǎn)品，的服務(wù)，簽約 KAMIYA就是為了給廣大科研客戶帶來更加完善的產(chǎn)品和服務(wù),您的滿意將是我們zui大的收獲

KAMIYA中國代理, KAMIYA上海代理， KAMIYA北京代理，KAMIYA廣東代理， KAMIYA江蘇代理KAMIYA湖北代理,KAMIYA天津,KAMIYA黑龍江代理,KAMIYA內(nèi)蒙古代理,KAMIYA吉林代理,KAMIYA福建代理, KAMIYA江蘇代理, KAMIYA浙江代理, KAMIYA四川代理,

Kamiya Biomedical Company是一家1983年3月成立的美國生命科學(xué)技術(shù)公司，總部位于美國加利福尼亞州。本公司致力于為生命科學(xué)研究和醫(yī)藥機(jī)構(gòu)提供高質(zhì)量的具有創(chuàng)新性的基礎(chǔ)研究和診斷試劑。

公司的zui早的生命科學(xué)研究產(chǎn)品是用于信號轉(zhuǎn)導(dǎo)研究用蛋白酶抑制劑staurosporine和K252a。1990年，KAMIYA*家在美國推出凋亡研究的重要抗體anti-Fas單克隆抗體。1997年推出了一個完整的臨床診斷和研究用免疫檢測產(chǎn)品線，生產(chǎn)基于免疫投射比濁法(immunoturbidimetric technology)的脂質(zhì)測定、凝血、炎癥、糖尿病、營養(yǎng)評估及血脂蛋白測定試劑及試劑盒。公司研發(fā)的K-ASSAY試劑無需攪拌、溶解和稀釋樣本等繁雜程序。

如今，KAMIYA供應(yīng)的生命科學(xué)系列產(chǎn)品包括世界上zui大的ELISA試劑盒產(chǎn)品線，上萬種人類的生物標(biāo)志物分析的產(chǎn)品、酶抑制劑、單抗、多抗。產(chǎn)品廣泛應(yīng)用于細(xì)胞凋亡、多抗藥性、氧化/ DNA損壞和修復(fù)、骨生物學(xué)、癌癥、心臟健康、炎癥、壓力與應(yīng)激、肥胖和糖尿病等研究領(lǐng)域。

zui近，KAMIYA又推出了創(chuàng)新性的基于K-ASSAY化學(xué)檢測試劑的胰島素、D-二聚體(D-Dimer)，F(xiàn)actor XIII，纖維蛋白原降解產(chǎn)物(Plasma FDP)，血清/尿液FPD及FDP-E(纖維蛋白原降解產(chǎn)物E片段)和總IgE等因子的檢測試劑。

KAMIYA現(xiàn)在擁有zui全的血清蛋白免疫檢測試劑產(chǎn)品線，為醫(yī)院、醫(yī)療中心、臨床實驗室、臨床參考實驗室、研究所等眾多機(jī)構(gòu)提供專業(yè)的臨床診斷和科研試劑產(chǎn)品。

品名: Anti-LSD1 pAb

貨號: PC-543 (100 µg)

Synonyms:Anti-Lysine-Specific Histone Demethylase, anti-Amine Oxidase Flavin Containing Domain Protein 2, anti-AOF2.

Format:100 µg of polyclonal antibody in PBS containing

0.02% sodium azide. Purified by immunoaffinity chromatography.

Background:

Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing co-repressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.

Storage: Store at 4°C.

Applications and Suggested Dilutions: Western blot:  Use at 1 - 2 µg/mL.

Immunohistochemistry:  Use at ~ 2 µg/mL.

The optimal dilution for a specific application should be determined by the researcher.

Figure 1: Western blot analysis of LSD1 in P815 cell lysate with anti-LSD1 pAb at (A) 1 µg/mL and (B) 2 µg/mL.

Specificity:  Recognizes LSD1.

Positive Control:  P815 cell lysate.

Species Reactivity:

Human, mouse and rat. Other species not tested.

Host:  Rabbit

Immunogen:

Raised against a 16 amino acid peptide from near the center of human LSD1 (Genbank accession No. NP_001009999).

Figure 2: Immunohistochemistry of LSD1 in human small intestine tissue with LSD1 antibody at 2 µg/mL.

Limitations:For in vitro research use only. Not for use in diagnostics or in humans.

Warranty:

No warranties, expressed or implied, are made regarding the use of this product. KAMIYA BIOMEDICAL COMPANY is not liable for any damage,

personal injury, or economic loss caused by this product.

我們公司zui大優(yōu)勢是強(qiáng)大的采購，

1：基本什么都能進(jìn)口，血清，抗體，耗材，還有部分限制進(jìn)口的，

2：貨品全，現(xiàn)經(jīng)營過700多個品牌，基本所有生物試劑耗材都可以進(jìn)口，特別是冷偏的產(chǎn)品那就更有優(yōu)勢，

3：提供加急服務(wù)，一般1-2周到貨，超過時限加急費(fèi)全免

4：價格公道，絕大部分價格有優(yōu)勢，當(dāng)然不能保證100%產(chǎn)品都是,因為意味著沒有服務(wù).

5：良好的信譽(yù)，大部分客戶我們提供貨到付款服務(wù)，客戶包括清華，北大 交大 復(fù)旦，中山等100多所大學(xué)，ROCHE，阿斯利康，國藥 ，fisher等500多家公司

6：我們*代理的品牌有：Antibody Research Corporation，arcticzymes，Biorelevant，AmberGen, Inc. ，clemente-associates，clodronaiposomes，Columbia Biosciences，enzyme research，Gene Bridges GmbH，Genovis，AmberGen, Inc.  Biotechnology GmbH，Haematologic Technologies HTI Haemtech，hookelabs，Immudex，Innovative Research of America，inspiralis ，List Biological Laboratories, Inc.，lumafluor，Microsurfaces，multiplicom，nanotools，Pel-Freez Biologicals，pentapharm，progen，Protein Ark，QA-Bio,Inc，QA-Bio,IncQuickZyme Biosciences，Teknova，TriLink BioTechnologies, Inc.，Zyagen Laboratories 等

7：我們還是invitrogen,qiagen,Midland BioProducts Corporationam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知名*批發(fā)，歡迎合作。